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A mathematical relationship between the fatty acid composition of the diet and that of the adipose tissue in man

by A C Beynen, R J Hermus, J G Hautvast

Abstract: Based on literature data, the hypothesis is advanced that in human subjects a direct mathematical relationship exists between the average fatty acid composition of the habitual diet and that of the lipid stores of subcutaneous adipose tissue. Since the half-life of adipose tissue fatty acids in man is in the order of 600 days, the fatty acid pattern of depot fat provides a qualitative measure of the fat intake over a period of 2 to 3 years. It is concluded that in long-term experimental and epidemiological nutritional surveys the adipose tissue fatty acid pattern of the subjects is a useful index of the average composition of their habitual dietary fat.
pufa

Meta-analysis reviewing studies that compare dietary fats to adipose fats in humans. It concludes that the half-life of fatty acid tissue is about 600 days, and it takes about 800-900 days to entirely replace the adipose tissue of an adult human (nearly 3 years). It mentions that very low fat diets seem to dilute the dietary fat via de novo lipogenesis, and the adipose fat will therefore not reflect the dietary fat closely. It also mentions that rapid fat loss/gain might influence the speed, the experiments were apparently largely done in weight stable people.

PMID: 7355785
Original source: https://pubmed.ncbi.nlm.nih.gov/7355785/