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BCAA dysmetabolism in the host and gut microbiome, a key player in the development of obesity and T2DM
by NaLiab, ZhipengCencd, ZhengdeZhaoab, ZilunLiab, SifanChencd
Abstract:
Highlights•BCAA metabolism significantly changes in the host and gut microbiome during obesity and T2DM development.•Dysregulated BCAA metabolism precedes obesity and T2DM development.•BCAAs and their metabolites interact with glucose and lipid metabolism in different tissues during obesity and T2DM development.•Normalized BCAA metabolism enhances metabolic homeostasis in obesity and T2DM.
Original source:
https://www.sciencedirect.com/science/article/pii/S2590097823000034