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bcaa

10 studies
BCAA dysmetabolism in the host and gut microbiome, a key player in the development of obesity and T2DM
by NaLiab, ZhipengCencd, ZhengdeZhaoab, ZilunLiab, SifanChencd
protein
bcaa
Dietary restriction of isoleucine increases healthspan and lifespan of genetically heterogeneous mice
by Cara L.Green, Michaela E.Trautman, KrittisakChaiyakul, RaghavJain, Yasmine H.Alam, RejiBabygirija, Heidi H.Pak, Michelle M.Sonsalla, Mariah F.Calubag, Chung-YangYeh, AnnelieseBleicher, GraceNovak, Teresa T.Liu, SarahNewman, Will A.Ricke, Kristina A.Matkowskyj, Irene M.Ong, CholsoonJang, JudithSimcox, Dudley W.Lamming
protein
bcaa
isoleucine
Dietary isoleucine content defines the metabolic and molecular response to a Western diet
by Michaela E.Trautman, Cara L.Green, Michael R.MacArthur, KrittisakChaiyakul, Yasmine H.Alam, Chung-YangYeh, RejiBabygirija, IsabellaJames, MichaelGilpin, EstherZelenovskiy, MadelynGreen, Ryan N.Marshall, Michelle M.Sonsalla, VictoriaFlores, View ORCID ProfileJudith A.Simcox, Irene M.Ong, Kristen C.Malecki, CholsoonJang, View ORCID ProfileDudley W.Lamming
protein
bcaa
isoleucine
A Branched-Chain Amino Acid-Related Metabolic Signature that Differentiates Obese and Lean Humans and Contributes to Insulin Resistance
by Christopher B Newgard, Jie An, James R Bain, Michael J Muehlbauer, Robert D Stevens, Lillian F Lien, Andrea M Haqq, Svati H. Shah, Michelle Arlotto, Cris A Slentz, James Rochon, Dianne Gallup, Olga Ilkayeva, Brett R Wenner, William E Yancy, Howard Eisenson, Gerald Musante, Richard Surwit, David S Millington, Mark D Butler, Laura P Svetkey
protein
bcaa
A Novel Dietary Intervention Reduces Circulatory Branched-Chain Amino Acids by 50%: A Pilot Study of Relevance for Obesity and Diabetes
by Imran Ramzan, Moira Taylor, Beth Phillips, Daniel Wilkinson, Kenneth Smith, Kate Hession, Iskandar Idris, Philip Atherton
protein
bcaa
Restricting Branched-Chain Amino Acids within a High-Fat Diet Prevents Obesity
by Ming Liu, Yiheng Huang, Hongwei Zhang, Dawn Aitken, Michael C. Nevitt, Jason S. Rockel, Jean-Pierre Pelletier, Cora E. Lewis, James Torner, Yoga Raja Rampersaud, Anthony V. Perruccio, Nizar N. Mahomed, Andrew Furey, Edward W. Randell, Proton Rahman, Guang Sun, Johanne Martel-Pelletier, Mohit Kapoor, Graeme Jones, David Felson, Dake Qi, Guangju Zhai
protein
bcaa
Altered Branched Chain Amino Acid Metabolism: Towards a Unifying Cardiometabolic Hypothesis
by Deirdre K. Tobias, Samia Mora, Subodh Verma, Patrick R. Lawler
protein
bcaa
Restoration of metabolic health by decreased consumption of branched‐chain amino acids
by Nicole E. Cummings, Elizabeth M. Williams, Ildiko Kasza, Elizabeth N. Konon, Michael D. Schaid, Brian A. Schmidt, Chetan Poudel, Dawn S. Sherman, Deyang Yu, Sebastian I. Arriola Apelo, Sara E. Cottrell, Gabriella Geiger, Macy E. Barnes, Jaclyn A. Wisinski, Rachel J. Fenske, Kristina A. Matkowskyj, Michelle E. Kimple, Caroline M. Alexander, Matthew J. Merrins, Dudley W. Lamming
protein
bcaa
The adverse metabolic effects of branched-chain amino acids are mediated by isoleucine and valine
by DeyangYu12312, Nicole E.Richardson12412, Cara L.Green12, Alexandra B.Spicer5, Michaela E.Murphy126, VictoriaFlores126, CholsoonJang78, IldikoKasza9, MariaNikodemova5, Matthew H.Wakai12, Jay L.Tomasiewicz1, Shany E.Yang12, Blake R.Miller12, Heidi H.Pak12, Jacqueline A.Brinkman12, Jennifer M.Rojas10, William J.QuinnIII10, Eunhae P.Cheng12, Elizabeth N.Konon12, Lexington R.Haider12, Dudley W.Lamming123461113
protein
bcaa
isoleucine
Having previously established the positive effects of protein restriction, and having narrowed it down to BCAA restriction, this experiment sought to test which of the 3 BCAAs is mediating the effect. It turned out to be mostly isoleucine, with valine playing a smaller role. FGF21 was shown to be part of what mediated the effects of isoleucine restriction.
Interplay between lipids and branched-chain amino acids in development of insulin resistance
by Christopher B Newgard
protein
bcaa
randle
The article reviews the literature about the Randle cycle and mitochondrial inertia, and develops a model to explain how lipids and BCAAs play together to promote insulin resistance. A literature review shows that BCAAs are associated with insulin resistance and diabetes more than any other metabolite studied. Yet the negative effects of BCAAs only seem to show up in "high-fat" diets. The authors therefore believe that BCAAs can "clog up" the TCA cycle similarly to lipids, possibly competing for similar pathways. This can then lead to glucose intolerance.