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Dietary restriction of isoleucine increases healthspan and lifespan of genetically heterogeneous mice
by Cara L.Green, Michaela E.Trautman, KrittisakChaiyakul, RaghavJain, Yasmine H.Alam, RejiBabygirija, Heidi H.Pak, Michelle M.Sonsalla, Mariah F.Calubag, Chung-YangYeh, AnnelieseBleicher, GraceNovak, Teresa T.Liu, SarahNewman, Will A.Ricke, Kristina A.Matkowskyj, Irene M.Ong, CholsoonJang, JudithSimcox, Dudley W.Lamming
Abstract:
Highlights•Isoleucine restriction (IleR) improves metabolic health in both sexes•IleR reprograms hepatic metabolism in a sex- and age-dependent manner•IleR reduces frailty and increases lifespan, with stronger effects on male lifespan•Amino acid restriction begun at 6 months extends healthspan but not lifespan