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Tag:
Tag:
isoleucine
3 studies
Dietary restriction of isoleucine increases healthspan and lifespan of genetically heterogeneous mice
by Cara L.Green, Michaela E.Trautman, KrittisakChaiyakul, RaghavJain, Yasmine H.Alam, RejiBabygirija, Heidi H.Pak, Michelle M.Sonsalla, Mariah F.Calubag, Chung-YangYeh, AnnelieseBleicher, GraceNovak, Teresa T.Liu, SarahNewman, Will A.Ricke, Kristina A.Matkowskyj, Irene M.Ong, CholsoonJang, JudithSimcox, Dudley W.Lamming
Dietary isoleucine content defines the metabolic and molecular response to a Western diet
by Michaela E.Trautman, Cara L.Green, Michael R.MacArthur, KrittisakChaiyakul, Yasmine H.Alam, Chung-YangYeh, RejiBabygirija, IsabellaJames, MichaelGilpin, EstherZelenovskiy, MadelynGreen, Ryan N.Marshall, Michelle M.Sonsalla, VictoriaFlores, View ORCID ProfileJudith A.Simcox, Irene M.Ong, Kristen C.Malecki, CholsoonJang, View ORCID ProfileDudley W.Lamming
The adverse metabolic effects of branched-chain amino acids are mediated by isoleucine and valine
by DeyangYu12312, Nicole E.Richardson12412, Cara L.Green12, Alexandra B.Spicer5, Michaela E.Murphy126, VictoriaFlores126, CholsoonJang78, IldikoKasza9, MariaNikodemova5, Matthew H.Wakai12, Jay L.Tomasiewicz1, Shany E.Yang12, Blake R.Miller12, Heidi H.Pak12, Jacqueline A.Brinkman12, Jennifer M.Rojas10, William J.QuinnIII10, Eunhae P.Cheng12, Elizabeth N.Konon12, Lexington R.Haider12, Dudley W.Lamming123461113
Having previously established the positive effects of protein restriction, and having narrowed it down to BCAA restriction, this experiment sought to test which of the 3 BCAAs is mediating the effect. It turned out to be mostly isoleucine, with valine playing a smaller role.
FGF21 was shown to be part of what mediated the effects of isoleucine restriction.